IgA Vasculitis Across the Ages: Is It Time for a Precision Medicine Approach?

ABSTRACT: IgA vasculitis (IgAV; formerly Henoch-Schönlein purpura) is a systemic small vessel vasculitis most commonly affecting the skin, gut, joints, and kidneys. Nephritis is the most concerning complication for all ages because it carries the risk of progression to irreversible end-stage kidney failure. The multiorgan nature of the disease, variation in clinical presentation, and unpredictable disease course pose a substantial challenge to timely diagnosis, risk stratification, and a unified approach to management. Precision medicine is defined as a health care approach that uses genetic and molecular profiling alongside phenotypic and environmental data to generate insights to prevent or treat disease. This review article aims to provide an overview of IgAV using the latest literature to highli

SUBMITTER: Gage A 

PROVIDER: S-EPMC12426765 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature