Personalized High-Definition Transcranial Direct Current Stimulation for the Treatment of Depression: A Randomized Clinical Trial.

ABSTRACT:

Importance

Transcranial direct current stimulation (tDCS) shows promise for treating depression. The precision and focality of stimulation may influence therapeutic outcomes; thus, investigation of personalized focal high-definition (HD) tDCS for treating depression is needed.

Objective

To determine whether HD-tDCS therapy can improve mood in patients with moderate to severe depression.

Design, setting, and participants

This randomized clinical trial used a double-blind, sham-controlled, parallel study design. The trial was conducted from December 1, 2020, to March 7, 2024, at UCLA. Each participant received a 4-week follow-up. Participants were required to meet diagnostic criteria for a current major depressive episode (evaluated using the Mini International Neuropsy

SUBMITTER: Jog MA 

PROVIDER: S-EPMC12426800 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature