Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization.

ABSTRACT:

Background

Lower socioeconomic status, intelligence, and cognition are linked to a higher likelihood of atrial fibrillation (AF). However, whether these factors directly cause AF or whether others mediate this relationship is unclear.

Objectives

Our study aimed to determine the causal link between lower socioeconomic status, intelligence, cognition, and AF, and identify mediators.

Methods

We conducted a 2-sample Mendelian randomization analysis with data from European ancestry genome-wide association studies. Genetic instruments for education, intelligence, cognition, income, and occupation (n = 248,847-1,131,881) evaluated their relationship with AF (FinnGen study: 50,743 cases and 210,652 control subjects; 6 European studies: 60,620 and 970,216).

Results

The

SUBMITTER: Kaisaier W 

PROVIDER: S-EPMC12426838 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature