Streamlined Synthesis and Immunomodulatory Effects of Ulvan Oligosaccharides from Marine Green Algae.

ABSTRACT: Green algae, commonly used as a source of food nutrients, contain ulvan, which is a water-soluble sulfated heteropolysaccharide isolated from Ulva. Ulvan exhibits a range of biological properties, including antitumor, antiviral, anticoagulant, and immunomodulatory activities. Its sugar backbone consists of 1→4-linked disaccharide repeating units, which are categorized as ulvanobiuronic acids (types A_3'S and B_3'S) and ulvanobioses (types U_3'S and U_2S3'S). Despite its promising therapeutic potential, the detailed structure-activity relationship of ulvan remains unclear. In this study, an efficient strategy was developed, utilizing orthogonally protected α1→4-linked l-Rha-d-Glc, l-Rha-l-Ido, and l-Rha-d-Xyl derivatives as disaccharide buildin

SUBMITTER: Shimabukuro J 

PROVIDER: S-EPMC12426931 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature