In silico exploring of the epigenetic factors in teratozoospermia: A focus on <i>IGF2BP2</i>.

ABSTRACT: Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been implicated in the regulation of gene expression in teratozoospermia, but the specific mechanisms are not fully understood. This study aimed to identify differentially expressed genes (DEGs) between teratozoospermia and normozoospermia samples, and to investigate the role of epigenetic regulatory factors in the observed gene expression changes. The study integrated data from three publicly available datasets in the GSE6969 superseries. The DEGs were compared to a list of known human epigenetic-related genes obtained from the EpiFactors database. The protein-protein interaction (PPI) network and hub gene identifications for Epi-DEGs and the RNA-protein interaction (RPI) n

SUBMITTER: Mousavi SZ 

PROVIDER: S-EPMC12426961 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature