Species-level taxonomic characterization of gut microbiota in HIV-infected individuals.

ABSTRACT: Most current HIV gut microbiota studies, based on 16S rRNA gene sequencing, are limited to the genus level. Since different genera encompass several to hundreds of species, in this study, we performed research at the species level based on the HGMAD database. This cross-sectional study investigated differences in gut microbiota between healthy control (HC) subjects and people with HIV (PWH) at the species level, characterized the specific enterotype and the correlation between gut microbiota patterns and immune status in PWH. We recruited 114 individuals in the PWH group and 58 individuals in the HC group, from whom fecal samples were collected for 16S rRNA gene sequencing of the V3-V4 region. Significant differences in α diversity and β diversity (p-values < 0.05) were observed bet

SUBMITTER: Chen J 

PROVIDER: S-EPMC12427029 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature