Ether-lipids accumulation promotes hepatocellular carcinoma progression linked to PPARα deficiency.

ABSTRACT:

Background

While the Warburg effect links glycolysis to de novo lipid synthesis in carcinogenesis, the roles of lipids in cancer prognosis remain elusive. Here, a multi-omics approach was conducted in a cohort of hepatocellular carcinoma (HCC) to elucidate the role of lipid metabolites as prognostic markers.

Methods

Ninety-eight HCC patients were recruited between 2011 and 2013. Their specimens were subjected to transcriptomic and lipidomic profiling. The resulting data were then analyzed using strategic bioinformatics approaches to identify associations with HCC prognosis. Subsequently, lipid-related pathways implicated in these analyses were verified using cellular and molecular approaches.

Results

Our findings indicate that lipidomic profiling is a potential progno

SUBMITTER: Liao PY 

PROVIDER: S-EPMC12427100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature