Small nucleolar RNA dysregulation and potential roles in bovine subclinical mastitis.

ABSTRACT:

Background

Subclinical mastitis, caused by many pathogens including Staphylococcus aureus (S. aureus) and Staphylococcus chromogenes (S. chromogenes), presents a major challenge to the dairy industry due to its associated economic losses and poor milk quality. The molecular regulatory mechanisms, including the role of small nucleolar RNAs (snoRNAs), of the host response to mastitis pathogens remain unclear. Therefore, this study investigated snoRNA expression and potential roles during subclinical mastitis. Milk somatic cells from cows with naturally occurring S. aureus (n = 14) and S. chromogenes (n = 3) subclinical mastitis, and healthy cows (n = 4) were subjected to transcriptome sequencing and bioinformatics analyses.

Results

We identified 255 expressed snoRNAs including

SUBMITTER: Omonijo FA 

PROVIDER: S-EPMC12427106 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature