Diminished Estrogen Induced Mitochondrial Protection and Immunosuppressive Microenvironment in Gastric Cancer with Depression.

ABSTRACT:

Background

It is established that depression significantly contributes to tumor development, yet its molecular link to gastric cancer progression remains unclear.

Methods

In this study, we examined depression-related gene expression profiles in relation to clinical prognosis and identified estradiol and the NOTCH3 gene as critical factors involved in gastric cancer progression in the context of depression. Using a chronic unpredictable stress-induced tumor-bearing mouse model, we validated the impact of depression on tumor development. Additionally, the underlying molecular mechanisms were explored through a range of biological techniques, including Western blotting, immunofluorescence, flow cytometry and immunohistochemistry.

Results

Depression significantly accelera

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12427221 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature