Pediatric pulmonary arterial hypertension: global epidemiology and disease burden during the period 1990 to 2021.

ABSTRACT:

Objectives

Pediatric pulmonary arterial hypertension (PAH) is a severe and potentially fatal disease; however, the global epidemiological burden of pediatric PAH has not been comprehensively elucidated.

Study design

The Global Burden of Diseases Study 2021 has incorporated PAH for the first time. This study analyzed the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) associated with pediatric PAH from 1990 to 2021.

Results

Globally, the age-standardized prevalence rate (ASPR) of pediatric PAH in children aged 0-14 years showed a relatively stable, from 0.44 per 100,000 in 1990 to 0.43 per 100,000 in 2021. Females exhibited higher age-standardized incidence rates (ASIR) and ASPR compared to males. The ASIR of pediatric PAH increased modestl

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12427251 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature