Radiomics Features from Different Prostatic Zones on ¹⁸F-PSMA-1007 PET/CT for Predicting Persistent PSA in Prostate Cancer Patients: A Multicenter Study.

ABSTRACT: Objectives: This study aims to explore the role of radiomics features (RFs) from prostate subregions, including the tumor microenvironment (TME), in predicting persistent PSA. Methods: In retrospective analysis, we segregated 354 patients with pathologically confirmed localized prostate cancer (PCa) into training, internal validation, and external validation cohorts. The prostate on ¹⁸F-prostate-specific membrane antigen (PSMA)-1007 positron emission tomography/computed tomography (PET/CT) was partitioned into three zones based on the maximum standardized uptake value (SUVmax) (zone-intra: 45-100% SUVmax; zone-peri: 20-45% SUVmax; zone-norm: 0-20% SUVmax). RFs from these zones were harnessed to develop five radiomics models [model-intra; model-peri; model-norm; mod

SUBMITTER: Li L 

PROVIDER: S-EPMC12427274 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature