<i>KRAS</i> Mutations in Colorectal Adenocarcinoma: Incidence and Association with Histological Features with Particular Reference to <i>Gly12Asp</i> in a Multicenter GIPAD Real-World Study.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer-related death worldwide. CRC is characterized by morphologic and biological heterogeneity, and molecular profiling is required to select appropriate treatment in the metastatic setting. Mutations in KRAS are detected in approximately 40% of CRCs, with prognostic and predictive value, and with the most frequent being p.G12D. Nonetheless, there are few data on the morphologic features in KRAS-mutated CRCs.

Materials and methods

We retrospectively collected clinicopathological features and molecular profiles of CRCs in a multicenter cohort.

Results

A total of 2816 patients from 12 centers were included. KRAS mutation was found in 47.4% of cases;

SUBMITTER: Parente P 

PROVIDER: S-EPMC12427293 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature