Predicting Absolute Risk of First Relapse in Classical Hodgkin Lymphoma by Incorporating Contemporary Treatment Effects.

ABSTRACT: Background/Objectives: There is a need for prediction models which enable weighing benefits against risks of different treatment strategies for individual Hodgkin lymphoma (HL) patients. Therefore, we aimed to predict absolute risk of progression, first relapse or death (PRD) with and without incorporating HL treatment. Methods: The prognostic and treatment information of 2343 patients treated for classical HL at ages 15-60 years between 2008 and 2018 in the Netherlands was used to predict absolute risk of PRD up to 5 years after diagnosis using Cox proportional hazard models allowing for time-varying coefficients. Models were externally validated in 1675 patients treated for classical HL in Denmark between 2000 and 2018. Results: In early stages, gender, leukocyte, an

SUBMITTER: Roshani S 

PROVIDER: S-EPMC12427322 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature