In Silico and In Vitro Evaluation of δ-cadinene from <i>Decatropis bicolor</i> as a Selective Inhibitor of Human Cell Adhesion and Invasion Proteins.

ABSTRACT: Background: Breast cancer is a complex, multifactorial malignancy characterized by the uncontrolled proliferation of epithelial cells, with certain subtypes exhibiting resistance to conventional therapies. Plant-derived essential oils have been proposed as potential anticancer agents due to their bioactive compounds. Recent studies have demonstrated that Decatropis bicolor essential oil exhibits activity against breast cancer, attributed to diverse secondary metabolites such as δ-cadinene. Aberrant expression of adhesion and invasion proteins, including MMPs, CD44, N-cadherin, and ZEB-2, are key signs of breast cancer progression and metastasis; they represent relevant molecular targets. Objectives: To investigate the interaction of δ-cadinene with these proteins using

SUBMITTER: Reyes-Vidal I 

PROVIDER: S-EPMC12427431 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature