Prognostic values and clinical significance of POU2F3 expression in neuroendocrine carcinomas: a meta-analysis with a focus on small cell lung cancer.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine carcinoma (NEC) with poor prognosis due to chemotherapy resistance. Molecular subtypes, including ASCL1, NEUROD1, YAP1 and POU2F3, have distinct clinical implications. POU2F3, linked to a tuft cell-like lineage, represents a non-neuroendocrine subtype found in SCLC and extrapulmonary NECs. However, its prognostic and clinical significance remain unclear.

Methods

A meta-analysis was performed to assess the relationship between POU2F3 expression and clinical outcomes in SCLC and NECs. Studies reporting clinicopathological or survival data related to POU2F3 expression, identified via immunohistochemistry, were included. This review was performed following the guidelines of the Preferred Report

SUBMITTER: Sung YE 

PROVIDER: S-EPMC12427452 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature