<i>Akkermansia muciniphila</i> ameliorates chronic stress-induced colorectal tumor growth by releasing outer membrane vesicles.

ABSTRACT: Genetic predisposition and environmental factors, including psychological stress, play prominent roles in driving the development and progression of colorectal neoplasms. However, the mechanisms through which chronic stress drives the progression of colorectal neoplasm remain unclear. The gut microbiota is closely linked to chronic psychological stress (chronic stress) and colorectal neoplasms. Here, we found that chronic stress significantly promoted tumor growth in patients with colorectal cancer and mouse models of colitis-associated colorectal cancer, while concurrently reducing the abundance of Akkermansia muciniphila in fecal and tumor samples. Restoring the A. muciniphila abundance mitigated the tumor-promoting effects of chronic stress. Furthermore, we identified A

SUBMITTER: Jin S 

PROVIDER: S-EPMC12427454 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature