Parity influences on the infant gut microbiome development: a longitudinal cohort study.

ABSTRACT: Parity, the number of pregnancies carried beyond 20 weeks, influences the maternal gut microbiome. However, whether parity modulates the infant microbiome longitudinally remains underexplored. To address this, 746 infants in a longitudinal cohort study were assessed. Serial infant stool samples collected at 2, 6, 12, and 24 months underwent 16S ribosomal RNA gene sequencing. Mothers were stratified by parity: 1 = 32.6%, 2 = 42.0%, 3 = 18.6%, 4, 5, 6 or 7 = 6.8%. Although no differences in alpha diversity were found with parity, significant differences were found in microbiome composition (beta diversity, Bray-Curtis) by parity at each time point through the first year of life (p < 0.001). Delivery mode (vaginal delivery (VD) = 60.5%, Cesarean section (CS) = 39.5%) was a significant

SUBMITTER: Prasad R 

PROVIDER: S-EPMC12427479 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature