Identification of multifunctional T-cell peptide epitopes for the development of DNA vaccines against dengue virus.

ABSTRACT: Dengue virus (DENV) is an important arthropod-borne virus that poses a global health threat, with half of the world's population at risk of infection. Currently, there is a lack of safe and effective vaccines for its prevention. Antibody-dependent enhancement (ADE) occurs when cross-reactive antibodies fail to neutralize heterologous DENV serotypes effectively, facilitating viral entry into Fc receptor-bearing cells and leading to more severe disease. It is reported that multifunctional T cells are closely related to the protective effects of the vaccine. We selected 25 peptide candidates based on predictions from the IEDB database and relevant literature. These peptides were validated to stimulate the production of multifunctional T cells. The DNA sequences of the corresponding peptides w

SUBMITTER: Sun N 

PROVIDER: S-EPMC12427499 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature