Synergistic Effects of Novel Xanthone Derivatives and Mild Hyperthermia in Ovarian Cancer: Insights from Gene Expression and In Silico Analyses.

ABSTRACT:

Background/objectives

In the fight against ovarian cancer, various therapies have been employed, with a strong focus on developing novel derivatives of existing substances.

Methods

In this study, we continue our research on novel xanthone derivatives in combination with mild hyperthermia, targeting ovarian cancer cell lines TOV-21G and SK-OV-3. Using qPCR arrays, we analyzed 84 cellular stress-related genes categorized into anti-oxidant and pro-oxidant enzymes, molecular chaperones, and xenobiotic metabolism including the cytochrome P450 group. Furthermore, we conducted in silico analyses to investigate the pathways of the most affected genes, gene set enrichment, and gene ontology.

Results

The most significant changes were observed in SOD2, SOD3, CYP2F1, CYP1B1, and

SUBMITTER: Rech J 

PROVIDER: S-EPMC12427508 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature