Two Decades of Outcomes and Quality of Life Following Pencil Beam Scanning Proton Therapy in Children and Adolescents with Rhabdomyosarcoma.

ABSTRACT:

Background

RMS is the most common soft tissue sarcoma in children. Pencil beam scanning proton therapy (PBS PT) enables highly conformal dose delivery with reduced exposure to surrounding healthy structures, making it particularly suited for RMS in critical anatomical regions. Long-term clinical outcome data for this new radiation technique are scarce.

Purpose

This study reports long-term outcomes and quality of life after PBS PT in children and adolescents with rhabdomyosarcoma (RMS).

Methods and materials

We retrospectively reviewed 114 children and adolescents with RMS (mostly embryonal, n = 100; 87.7%) treated between 2000 and 2020. Their median age was 4.6 years (range, 0.3-18). All received systemic chemotherapy according to prospective protocols. The med

SUBMITTER: Leiser D 

PROVIDER: S-EPMC12427509 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature