Urinary Metabolome Study for Monitoring Prostate Cancer Recurrence Following Radical Prostatectomy.

ABSTRACT:

Background/objectives

Prostate cancer (PCa) is the most common cancer among males. Approximately 20-40% of patients with clinically localized PCa will present with a biochemical recurrence after a radical prostatectomy (RP), while some will present with recurrent metastasis. Monitoring the disease post-treatment is crucial for detecting a potential cancer recurrence early. Urinary volatile organic compounds (VOCs) have shown potential to detect PCa. However, their application in disease monitoring remains unexplored.

Methods

A total of 165 urine samples were collected from male adults with biopsy-designated PCa-positive results before (n = 55) and after a RP (n = 55), and with biopsy-designated PCa-negative diagnosis (n = 55). The post-RP cohort was subd

SUBMITTER: Badmos S 

PROVIDER: S-EPMC12427525 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature