Impact of High-Grade Glioma Lesion Location on Preoperative Neuropsychological Deficits.

ABSTRACT: Background: Glioblastoma (GBM) is an aggressive brain tumor, with surgery being an integral part of treatment. Aggressive resections improve clinical outcomes but need to be balanced against potential functional impairment. Neuropsychological (NP) testing is an important tool neurosurgeons use to assess cognitive functioning. Importantly, associations between NP test scores and imaging biomarkers could enable a testable baseline by which to track patient outcomes over time and aid in presurgical counseling. Methods: We identified 44 patients diagnosed with primary GBM and who had detailed NP testing and presurgical imaging. Regression models for NP indices were created with tumor size, hemisphere, and lobar location as predictors. Lesion-symptom mapping (LSM) analyses were us

SUBMITTER: Houskamp EJ 

PROVIDER: S-EPMC12427565 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature