Independent and combined adverse effects of neurocognitive impairment and depression on everyday functioning and quality of life in people with HIV.

ABSTRACT:

Objective

Despite advances in antiretroviral treatment (ART), human immunodeficiency virus (HIV) can detrimentally affect everyday functioning. Neurocognitive impairment (NCI) and current depression are common in people with HIV (PWH) and can contribute to poor functional outcomes, but potential synergies between the two conditions are less understood. Thus, the present study aimed to compare the independent and combined effects of NCI and depression on everyday functioning in PWH. We predicted worse functional outcomes with comorbid NCI and depression than either condition alone.

Methods

PWH enrolled at the UCSD HIV Neurobehavioral Research Program were assessed for neuropsychological performance, depression severity (≤minimal, mild, moderate, or severe; Beck Depression Inv

SUBMITTER: Wang CX 

PROVIDER: S-EPMC12427598 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature