Egg Yolk Granule Nanoparticles Promote Longitudinal Bone Growth in HFD-Obese Mice.

ABSTRACT: The relationship between obesity and bone development remains uncertain and requires further study. Egg yolk granules (EYGs), due to their high content of phosvitin (PV), are speculated to have the potential to promote bone growth. And EYGs nanoparticles (EYG NPs) may help improve their digestibility. This study aimed to evaluate the effects of EYG NPs on longitudinal bone growth in high-fat diet-induced obese mice. EYG NPs were prepared by treating EYGs with (NaPO₃)₆ and ultrasonication, then characterized. The simulated gastrointestinal digestion experiment indicated that the modification of EYG significantly enhanced the digestibility of PV. After 12 weeks of intervention, body growth indicators, serum bone metabolism markers, tibial length, bone mineral density (B

SUBMITTER: Xue W 

PROVIDER: S-EPMC12427661 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature