Research on the Genetic Polymorphism and Function of <i>inlA</i> with Premature Stop Codons in <i>Listeria monocytogenes</i>.

ABSTRACT: Listeria monocytogenes is a Gram-positive bacterial species that causes listeriosis, a major foodborne disease worldwide. The virulence factor inlA facilitates the invasion of L. monocytogenes into intestinal epithelial cells expressing E-cadherin receptors. Naturally occurring premature stop codon (PMSC) mutations in inlA have been shown to result in the production of truncated proteins associated with attenuated virulence. Moreover, different L. monocytogenes strains contain distinct inlA variants. In this study, we first characterized inlA in 546 L. monocytogenes strains isolated from various foods in Shanghai. The results showed that 36.1% (95% Confidence Interval: 32.0~40.2%) of the food isolates harbored inlA with PMSC, w

SUBMITTER: Liu X 

PROVIDER: S-EPMC12427964 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature