Development of Conjugated Linoleic Acid Nanostructured Lipid Carriers and Their Synergistic Efficacy with Curcumin.

ABSTRACT: Curcumin has good anti-cancer and antioxidant properties. However, the poor water solubility and low bioavailability limit its application in food products. This study constructed a nanostructured lipid carrier (Cur-CLA-NLC) encapsulating curcumin using conjugated linoleic acid (CLA) as the liquid lipid and stearic acid as the solid lipid. Cur-CLA-NLC exhibits significantly enhanced bioaccessibility, antioxidant activity, and cytocompatibility. CLA, as a liquid lipid in Cur-CLA-NLC, has a dual role as a structural stabilizer and bioactive agent, and synergistically enhances antioxidant activity with curcumin. In vitro simulated digestion studies showed that the bioaccessibility of curcumin in Cur-CLA-NLC (85.7%) was much higher than that in the pure curcumin (11.7%) and curcumin lipid mixt

SUBMITTER: Liu H 

PROVIDER: S-EPMC12427970 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature