Comparative Analysis of the Fecal Proteome in Two Canine Breeds: Dalmatians and Weimaraners.

ABSTRACT: The analysis of proteins in stool samples can significantly enhance the study of mammalian physiology and disease. In this study, we investigated the fecal proteome of clinically healthy dogs (n = 26) by a label-free proteomics approach to evaluate the impact of breed differences. The dogs were divided into two groups (n = 13 each) based on their breed, specifically Weimaraner and Dalmatian, the former known for their possible susceptibility to gastrointestinal disease. Quantitative and qualitative differences between the two experimental groups were identified based on analyses performed on pooled biological samples. The overall fecal proteome profile comprised 58 proteins, of which 37 were common, while comparative proteomics analysis detected 15 proteins with different abundances. Notab

SUBMITTER: Cerquetella M 

PROVIDER: S-EPMC12428007 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature