Context-Dependent Modulation of Breast Cancer Cell E-Cadherin Expression, Mitogenesis, and Immuno-Sensitivity by Immortalized Human Mesenchymal Stem Cells In Vitro.

ABSTRACT: The major event that leads to death from breast cancer (BrCa) is the emergence of micrometastases into lethal growing metastases. While it is still uncertain what regulates the cell fate decision between remaining in dormancy and aggressive proliferative progression, accumulating evidence demonstrates a major role for the metastatic microenvironment. One area of interest is that of tissue and circulating mesenchymal stem cells (MSCs), which have been shown to alter the proliferative and metastatic potential of BrCa. Herein, we investigate how these cells impact the phenotype of metastatic BrCa. As the disseminated BrCa cells initially adopt an epithelial phenotype in ectopic organs, one that is dormant in having limited proliferation and being immune-silent, interactions that revert the di

SUBMITTER: Dai B 

PROVIDER: S-EPMC12428074 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature