Nested Melanoma and Superficial Spreading Melanoma with Prominent Nests-A Retrospective Study on Clinical Characteristics and PRAME Expression.

ABSTRACT: Background: Nested melanoma is a rare subtype of superficial spreading melanoma. Due to its typical histology, characterized by the predominance of large melanocytic nests in an extensive horizontal spread, it is challenging to distinguish it from other benign nested melanocytic lesions. There is a need to identify additional histopathological parameters that can support the diagnosis of nested melanoma. Methods: In this retrospective case-control study, we analyzed immunohistochemical staining for PRAME in 10 cases of superficial spreading melanoma with prominent nests and 26 nested melanomas. Dysplastic melanocytic nevi were used as the control group. Results: We found a diffuse PRAME positivity (>75% of melanocytes) in 60% of superficial spreading melanoma with prom

SUBMITTER: Lenders D 

PROVIDER: S-EPMC12428223 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature