Characterization of an Extensively Drug-Resistant <i>Salmonella</i> Kentucky ST198 Co-Harboring <i>cfr</i>, <i>mcr-1</i> and <i>tet</i>(A) Variant from Retail Chicken Meat in Shanghai, China.

ABSTRACT: The emergence of extensively drug-resistant (XDR) foodborne pathogens poses grave threats to food safety. This study characterizes the genome of an XDR Salmonella Kentucky isolate (Sal23C1) co-harboring cfr, mcr-1 and tet(A) from Shanghai chicken meat in 2022, which was the only isolate co-harboring these three key resistance genes among 502 screened Salmonella isolates. Genomic analysis revealed that the multidrug resistance gene cfr, which confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A, was identified within a Tn3-IS6-cfr-IS6 structure on the transferable plasmid p3Sal23C1 (32,387 bp), showing high similarity to the Citrobacter braakii plasmid pCE32-2 (99% cover

SUBMITTER: Zhan Z 

PROVIDER: S-EPMC12428260 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature