Genome-Wide Identification of Solute Carrier Family 12 and Functional Characterization of Its Role in Saline-Alkaline Stress Acclimation in the Ridgetail White Shrimp <i>Exopalaemon carinicauda</i>.

ABSTRACT: Solute carrier family 12 (SLC12) encodes electroneutral cation-coupled chloride cotransporters responsible for transmembrane ion transport (Na⁺, K⁺, and Cl^-), which play a critical role in aquatic osmoregulation. However, the SLC12 gene of Exopalaemon carinicauda (EcSLC12) has not been systematically identified or functionally characterized. In this study, six EcSLC12 genes were identified across the genome and classified into N(K)CC, KCC, CCC9, and CIP subfamilies. Three NKCC1 homologous genes (EcSLC12A2.1, EcSLC12A2.2, and EcSLC12A2.3) were reported for the first time in crustaceans. The EcSLC12 family exhibited distinct expression patterns in response to low-salinity, high-alkalinity,

SUBMITTER: Tang S 

PROVIDER: S-EPMC12428425 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature