Profiling of Breast Cancer Stem Cell Types/States Shows the Role of CD44^hi/CD24^lo-ALDH1^hi as an Independent Prognostic Factor After Neoadjuvant Chemotherapy.

ABSTRACT: Multiple markers exist for breast cancer stem cells (CSCs), which are believed to represent the phenotypes of various CSC types and/or states. The relationship between each CSC subpopulation/state and the primary hallmarks of cancer has not been sufficiently clarified. In this study, six CSC markers (CD44^hi/CD24^lo, CD24, Ep-CAM, ALDH1, CD10, and BMI1) were assessed in a surgical cohort of 73 breast cancer patients. The expression of a single or multiple CSC markers was correlated with clinicopathological parameters, including markers of immune evasion, proliferation, epithelial-mesenchymal transition (EMT), and survival. All CSC phenotypes, except for CD10, correlated with markers indicative of higher proliferation. The CD44^hi/CD24^lo phenotype co

SUBMITTER: Ghebeh H 

PROVIDER: S-EPMC12428598 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature