Variability in the Deformability of Red Blood Cells: Application to Treating Premature Newborns with Blood Transfusion.

ABSTRACT: Blood units are routinely collected from adult donors and stored as packed red blood cells (PRBC). The quality of PRBC, including their deformability, decreases during storage. Since PRBC transfusion has been reported to promote circulatory issues in premature neonates (PNs), they typically receive freshly stored units. To test the hypothesis that freshly stored PRBCs can provide red blood cells (RBCs) with appropriate deformability for PN recipients, we compared the deformability of PRBCs transfused to PNs with that of cord blood RBCs (CRBCs), which are known to have deformability equivalent to that of newborn RBCs (PN-RBC). We found that, on average, CRBC deformability was higher than that of PRBCs. However, both showed significant variability with overlapping ranges. A highly significan

SUBMITTER: Arbell D 

PROVIDER: S-EPMC12428727 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature