Rotational Thromboelastometry (ROTEM) Hemostasis Profile in Pregnant Women with Preeclampsia and Their Offspring: An Observational Study.

ABSTRACT: Background/Objectives: Conventional Coagulation Tests (CCTs) fail to accurately reflect Preeclampsia's (PE's) coagulation status, disease progression, and hemostatic alterations. They do not differentiate between the normal hypercoagulability of healthy pregnancies and the pathological hypercoagulability associated with PE. Rotational Thromboelastometry (ROTEM) analyzes clot dynamics from initiation through amplification and propagation to termination and fibrinolysis. However, their application in PE, particularly in neonates born to women with PE, is limited. We aimed to identify the hemostatic alterations in pregnant women with PE using ROTEMs that remain undetected by CCTs and to assess PE's impact on neonatal hemostasis at birth. Methods: This was a single-center observa

SUBMITTER: Kontovazainitis CG 

PROVIDER: S-EPMC12428756 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature