TRILOGY: Discovery of sequence-structure patterns across diverse proteins.

ABSTRACT: We describe a new computer program, trilogy, for the automated discovery of sequence-structure patterns in proteins. trilogy implements a pattern discovery algorithm that begins with an exhaustive analysis of flexible three-residue patterns; a subset of these patterns are selected as seeds for an extension process in which longer patterns are identified. A key feature of the method is explicit treatment of both the sequence and structure components of these motifs: each trilogy pattern is a pair consisting of a sequence pattern and a structure pattern. Matches to both these component patterns are identified independently, allowing the program to assign a significance score to each sequence-structure pattern that assesses the degree of correlation between the corresponding sequence and stru

SUBMITTER: Bradley P 

PROVIDER: S-EPMC124288 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature