Identification of Inflammation Markers as Novel Potential Predictors of the HIV-DNA Reservoir Size.

ABSTRACT: The dynamics of the HIV reservoir during antiretroviral therapy (ART) exhibit variability, with a pronounced decline during the initial years of treatment. However, the identification of biomarkers and host factors associated with the decay of the different forms of HIV proviruses remains to be fully elucidated. We conducted a longitudinal study on people with HIV provided by the Spanish National HIV cohort. We assessed the HIV-DNA levels by Intact Proviral DNA Assay, and inflammatory markers using the Proximity Extension Assay, before and after ART initiation. A multivariate linear regression model was employed to identify potential predictive markers. Our results highlight the identification of novel inflammatory markers, such as ADA, DNER, CDCP1, SCF, among others, that varied significa

SUBMITTER: De La Torre Tarazona E 

PROVIDER: S-EPMC12428898 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature