Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization.

ABSTRACT: Gadolinium-based contrast agents revolutionized magnetic resonance imaging (MRI) by accelerating spin relaxation. In contrast, agents that decelerate relaxation were hitherto unknown. Such agents are highly desirable for metabolic imaging with hyperpolarized tracers such as ¹⁵N-pyridine, 1,4-¹³C₂-succinate, and 1-¹⁵N-nicotinamide, where valuable polarization decays rapidly, especially at low fields during transfer between polarizer and scanner. Here, we report on a previously unrecognized effect in which the tracers' longitudinal and transverse relaxation rates in aqueous solution are substantially reduced by adding nicotinamide, urea, glycerol, or dendrons. The impact on longitudinal relaxation is particularly pronounced at low magnetic fields a

SUBMITTER: Peters JP 

PROVIDER: S-EPMC12429058 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature