The Generation of iPSCs Expressing Interferon-Beta Under Doxycycline-Inducible Control.

ABSTRACT: Type 1 interferons (IFN-Is) exhibit significant antiviral, antitumor, and immunoregulatory properties, demonstrating substantial therapeutic potential. However, IFN-Is are pleiotropic cytokines, and the available data on their effect under specific pathological conditions are inconclusive. Furthermore, the systemic administration of IFN-Is can result in side effects. Generating cells that can migrate to the pathological focus and provide regulated local production of IFN-Is could overcome this limitation and provide a model for an in-depth analysis of the biological and therapeutic effects of IFN-Is. Induced pluripotent stem cells (iPSCs) are a valuable source of various differentiated cell types, including human immune cells. In this study, we describe the generation of genetically modifi

SUBMITTER: Sheveleva O 

PROVIDER: S-EPMC12429120 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature