Functionalized Indolizines as Potential Anticancer Agents: Synthetic, Biological and In Silico Investigations.

ABSTRACT: Three new series of indolizines (5a-f, 6a-f and 7a-g), functionalized with bromine or ethyl ester substituents on the pyridine ring, were designed and synthesized as promising anticancer agents. The synthesis of indolizine derivatives was carried out using the 1,3-dipolar cycloaddition of pyridinium N-ylides to ethyl propiolate as a key step. Spectral characterization (using NMR, FT-IR, HRMS and X-ray diffraction) showed that two types of cycloadducts 5a-f and 6a-f were obtained when the ylides generated by the 3-bromopyridinium salts were used as 1,3-dipoles in Huisgen cycloaddition reactions to ethyl propiolate. The anticancer effect of selected compounds was in vitro assessed against the National Cancer Institu

SUBMITTER: Ciorteanu R 

PROVIDER: S-EPMC12429123 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature