Pathologic outcome of incidentally detected tracer-avid lesions in ⁶⁸Ga-PSMA-11 PET/CT for prostate cancer.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA) PET is effective in identifying prostate cancer metastases. However, PSMA PET uptake has also been described in other lesions, including nonprostate malignancies and benign processes.

Purpose

To identify causes of unexpected radiopharmaceutical accumulation on PSMA PET.

Materials and methods

A total of 2,054 study reports representing 1,873 unique patients who had undergone ⁶⁸Ga-PSMA-11 PET/CT scans at a single large academic center from December 2015 to April 2022 were retrospectively reviewed for the mention of unexpected PSMA uptake not initially thought to represent metastatic prostate cancer. Scans with pathologic outcome were reviewed by 2 blinded readers for scan indication and lesion location and

SUBMITTER: Mar D 

PROVIDER: S-EPMC12429197 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature