<i>Bacteroides fragilis</i> and <i>Microbacterium</i> as Microbial Signatures in Hashimoto's Thyroiditis.

ABSTRACT: Hashimoto's thyroiditis (HT) and alopecia areata (AA) are organ-specific autoimmune diseases that frequently co-occur, suggesting shared immunological and microbial pathways. The gut microbiome has emerged as a key modulator of immune function, yet disease-specific microbial signatures remain poorly defined. Fecal samples from 51 participants (HT: n = 16, AA: n = 17, healthy controls: n = 18) aged 18-65 years were analyzed using shotgun metagenomic sequencing followed by multivariate statistical analyses. While alpha and beta diversity did not differ significantly across groups, taxonomic profiling revealed disease-specific microbial patterns. Bacteroides fragilis was significantly enriched in HT, suggesting a potential role in immune modulation; although mechan

SUBMITTER: Kovenskiy A 

PROVIDER: S-EPMC12429219 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature