In Vivo Response of γδ T Cells and Macrophages to Non-Bilayer Phospholipid Arrangements in a Lupus-like Mouse Model.

ABSTRACT: Anti-lipid autoantibodies are produced in systemic lupus erythematosus (SLE). These antibodies are associated with clinical manifestations of the disease, such as thrombosis, cardiovascular events, and neurological disorders. However, the cellular and molecular mechanisms that lead to the production of these antibodies are not well known. We developed a mouse model of lupus by administering liposomes bearing non-bilayer phospholipid arrangements (NPA) stabilized by chlorpromazine. These mice produce anti-NPA antibodies that trigger a lupus-like disease. In previous studies, we demonstrated that these antibodies are primarily produced by germinal centers and that NK1.1⁺ CD4⁺ T cells provide help to B cells, enabling them to produce these IgG antibodies. However, additi

SUBMITTER: Galarce-Sosa I 

PROVIDER: S-EPMC12429272 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature