Mitigation of T₁ impact for unbiased tumor magnetic resonance amide proton transfer imaging at 3T.

ABSTRACT:

Background

Amide proton transfer (APT), a specific type of chemical exchange saturation transfer (CEST) MRI, has proved valuable in tumor diagnosis and characterization by detecting mobile protein/peptides in cancerous tissues. However, T₁ confounds CEST measurements, leading to reduced specificity to amides and potential misinterpretation of APT imaging.

Purpose

The study aimed to investigate the feasibility of the quasi-steady-state (QUASS)-based apparent exchange-dependent relaxation (AREX) analysis in correcting T₁ for unbiased tumor APT MRI at 3T.

Materials and methods

CEST MRI experiments were conducted on an egg white phantom and on prospectively enrolled brain tumor patients with T₁ values modulated by gadolinium (Gd). QUASS al

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12429276 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature