Clinical Predictors of Underlying Histologic Activity in Patients with Lupus Nephritis: A Focus on Urinary Soluble CD163.

ABSTRACT: Background/Objectives: We sought to evaluate the clinical predictors of underlying histologic activity in patients with lupus nephritis (LN), with a focus on urinary soluble protein CD163 (usCD163). Methods: We conducted a retrospective, cross-sectional study of forty-two consecutive LN patients with concurrent determination of usCD163 at the moment of kidney biopsy. A first morning void prior to the kidney biopsy was collected and usCD163 was measured by a commercial ELISA assay (EUROIMMUN, Lubeck, DE). Results: The study cohort had a median age at the moment of kidney biopsy of 33.5 (IQR: 24-42.7) years. The mean eGFR and median 24 h proteinuria were 76.6 ± 33.9 mL/min/1.73 m² and 1.98 (IQR: 0.83-4.52) g/day. The median activity (AI) and chronicity (CI) in

SUBMITTER: Obrisca B 

PROVIDER: S-EPMC12429280 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature