The Role of Brachytherapy in the Management of Oral Squamous Cell Carcinoma: A Systematic Review.

ABSTRACT: Background: This systematic review evaluates the effectiveness and safety of brachytherapy (BT), including low-dose-rate (LDR) and high-dose-rate (HDR) techniques, in the treatment of oral squamous cell carcinoma (OSCC). Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science up to April 2025, according to PRISMA guidelines. The review was registered in PROSPERO (CRD42024581512). Eligible studies included cohort, case-control, and longitudinal studies in English investigating BT in OSCC patients. Risk of bias was assessed using ROBINS-I. Results: A total of 26 studies with 2286 patients were included where BT was employed as primary or adjuvant therapy, primarily for tumors of the tongue and floor of the mouth. Local control rates ranged from 7

SUBMITTER: Esperouz F 

PROVIDER: S-EPMC12429441 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature