The Effect of Aerobic Exercise Training on Patients with Type III Spinal Muscular Atrophy.

ABSTRACT: Background: Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by variants in the SMN1 gene. This study investigates the functional and biochemical effects of moderate-intensity aerobic exercise in SMA Type III patients. Methods: Twenty-three patients aged 18-57 years were included in this study. The training group underwent a 12-week aerobic exercise program using a bicycle ergometer at 60-70% of their maximum heart rate three times per week for 30 min per session. The training continued for an additional four months. The primary outcome measures were the six-minute walk distance and oxygen uptake, both reflecting exercise capacity. Secondary outcome measures included muscle strength with dynamometer, functional performance, and fatigue with differen

SUBMITTER: Mergen Kilic S 

PROVIDER: S-EPMC12429496 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature