Macrolide Therapy in Patients with Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Sepsis and septic shock are associated with markedly increased mortality. Some studies have suggested that macrolides improve outcomes independent of the antibiotic effects, possibly through immunomodulation. This study aimed to determine the effectiveness of macrolides in treating sepsis and septic shock. Methods: We searched electronic biomedical databases to investigate the effects of macrolide therapy versus non-macrolide therapy in patients with sepsis or septic shock. The primary outcome was overall mortality, which was also analyzed across subgroups according to the primary cause of sepsis and type of macrolides. Secondary outcomes consisted of the intensive care unit (ICU) length of stay (LOS) and hospital LOS. We calculated pooled risk ratio (RR) and mean

SUBMITTER: Kim K 

PROVIDER: S-EPMC12429649 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature