Frequency of Polymorphisms in <i>SLC47A1</i> (rs2252281 and rs2289669) and <i>SLC47A2</i> (rs34834489 and rs12943590) and the Influence of <i>SLC22A1</i> (rs72552763 and rs622342) on HbA1c Levels in Mexican-Mestizo Patients with DMT2 Treated with Metformin Monotherapy.

ABSTRACT: Diabetes type 2 (DT2) entails significant health, economic, and productivity repercussions around the world. Poor glycaemic control, defined as an HbA1c >7.0%, has been associated with a number of complications. In spite of the large share of healthcare resources allocated to DT2 treatment, the proportion of controlled Mexican patients is among the lowest in the world (34.4%). Certain protein-encoding genetic polymorphisms involved in metformin transport may affect glycaemic control. We focused on determining the frequency of rs2289669, rs2252281, rs12943590, and rs34834489 polymorphisms in Mexican-Mestizo patients from the Tertiary Care Regional Hospital of Ixtapaluca, State of Mexico, Mexico, as well as assessing their possible association with therapeutic efficacy, as estimated through

SUBMITTER: Gomez-Hernandez MA 

PROVIDER: S-EPMC12429666 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature