Quantification of Normative Human Choriocapillaris Measures Across the Macula.

ABSTRACT:

Purpose

To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).

Methods

Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula. En face projections of the CC at 1° intervals across the strip were created and metrics extracted using custom software.

Results

CC density was mostly invariant across t

SUBMITTER: Hammer DX 

PROVIDER: S-EPMC12429709 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature