Regulation of the lncRNA <i>malat1</i>/Egr1 axis by Wnt, Notch, and TGF-β signaling: a key mechanism in retina regeneration.

ABSTRACT: Unlike mammals, upon injury, adult zebrafish retinas rely on their ability to reprogram resident Müller glia to progenitor cells, enabling regeneration and restoration of vision. Retina regeneration remains incomplete in mammals despite extensive efforts to stimulate zebrafish regenerative conditions. Here, we show that the zebrafish lncRNA malat1 (metastasis-associated lung adenocarcinoma transcript 1), crucial for many biological functions, plays essential roles during retina regeneration. We demonstrate that zebrafish malat1 functions through an Egr1-dependent axis, modulated by Wnt, Notch, and TGF-β signaling pathways, and is necessary for effective retina regeneration. We performed RNA immunoprecipitation to establish the association of zebrafish malat1 with epige

SUBMITTER: Premraj S 

PROVIDER: S-EPMC12430008 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature